Toxikologi umeå
Research Current research projects as main project leader: Experimental design aligned with dose-response modelling as a means for 3R in toxicity testing Financial support: Vetenskapsrådet Bayesian dose-response modelling aligned with experimental design as means to improve chemical risk assessment Financial support: Formas Risk, Fara, Oro, Skada - ett kommunikationsprojekt Finansiering: Formas Kemiska olyckor i arbetslivet — systematisk analys av Giftinformationscentralens arbetsmiljörelaterade data Financial support: AFA Försäkring Other reasech projects: PERFORCE3, a Innovative Training Network about perfluorinated chemicals.
I have been the main supervisor for three PhD students:. As part of my research, I have studied the health risks related to airbourne chemicals, the effects of susceptible groups like asthmatics, and how the dose-response relationships can be calculated. The fourth season of Riskzonen was released in spring, summer, and autumn and was produced in collaboration with the Centre for Health Crises. Discrepancy among acute guideline levels for emergency response.
Calls made to the Poisons Information Centre reveal need for improved risk management of cleaning agents in the workplace. From cohorts to molecules: Adverse impacts of endocrine disrupting mixtures. My main area of research is health risk assessment of chemicals. Indigenous children living nearby plantations with chlorpyrifos-treated bags have elevated 3,5,6-trichloropyridinol TCPy urinary concentrations.
Benchmark dose-response analyses for multiple endpoints in drug safety evaluation. Inhibitory effects on osteoblast differentiation in vitro by the polychlorinated biphenyl mixture Aroclor are mainly associated with the dioxin-like constituents. Incorporating regulatory guideline values in analysis of epidemiology data. Together with epidemiologist Emma Frans, I have produced and hosted the podcast series Riskzonen.
Does industry take the susceptible subpopulation of asthmatic individuals into consideration when setting derived no-effect levels? High throughput screening of bisphenols and their mixtures under conditions of low-intensity adipogenesis of human mesenchymal stem cells hMSCs. Pharmacology and toxicology. Toxicity of Bromkal DE, a technical mixture of polybrominated diphenyl ethers, following 28 d of oral exposure in rats and impact of analysed impurities.
Worldwide burden of disease from exposure to second-hand smoke: a retrospective analysis of data from countries. Kursen ger kunskap om hur läkemedel verkar och om hur de fördelas och omsätts i kroppen. Records from the Swedish poisons information centre as a means for surveillance of occupational accidents and incidents with chemicals. I have also participated in the decision support system used by MSB the Swedish Civil Contingencies Agency and are regularly lecturing in emergency toxicology, preparedness and response.
Exposure to dioxin-like pollutants via different food commodities in Swedish children and young adults. Each episode provides a scientific perspective on events that have shaken the world and impacted how we view risks. My teaching activities include lectures, course leadership, supervising master and PhD student. Toxicology brought to justice: Risk assessments and liability assessments related to high levels of PFAS.
Teaching My teaching activities include lectures, course leadership, supervising master and PhD student. Identification of phthalate mixture exposure targets in the human and mouse ovary in vitro. Advancing the 3Rs in regulatory toxicology - Carcinogenicity testing: Scope for harmonisation and advancing the 3Rs in regulated sectors of the European Union. Vidare ger den kunskap om läkemedels och andra kemiska ämnens negativa effekter på den levande organismen och på miljön.
Benchmark dose approaches in chemical health risk assessment in relation to number and distress of laboratory animals. Adult smoking as a proxy for environmental tobacco smoke exposure among children - Comparing the impact of the level of information in Estonia, Finland and Latvia. Exempel på i kursen ingående moment: Allmän farmakologi inkluderande principer för hur. The point of transition on the dose-effect curve as a reference point in the evaluation of in vitro toxicity data.
Identification of the tryptophan photoproduct 6-formylindolo[3,2- b ]carbazole, in cell culture medium, as a factor that controls the background aryl hydrocarbon receptor activity. Här tar han oss med från stenåldern och bronsåldern till talet och blyad bensin, nobelprisforskning om jordens ålder och insamling av mjölktänder från klassens busar.
Gunnar Nordberg
The choice of critical effect size - a retrospective analysis on the risk assessment of PFAS. Disaster toxicology and the War in Ukraine: In relation to the War in Ukraine there is a risk of release of chemicals from damaged chemical industry and transportation of dangerous goods. Current modeling practice may lead to falsely high benchmark dose estimates. E-mail: mattias. I have been the main supervisor for three PhD students: Mia Johansson - Asthmatics as a susceptible population in health risk assessment of airbourne chemicals Joakim Ringblom - Worth weighting for - Studies on benchmark dose analysis in relation to animal ethics in toxicity testing Antero Silva planned dissertation in - Benchmark dose modelling for hazard and risk characterisation of chemicals Lars Brunken planed dissertation - Dose-response assessment of PFAS mixtures in relation to biomarkers of effects relevant for cardiovascular disease in humans.
Dose-dependent toxicological effects in rats following a day dietary exposure to PCB include retinoid disruption.
Mattias Öberg
Orcid LinkedIn X. About me My main area of research is health risk assessment of chemicals. Comparison of airway response in naive and ovalbumin-sensitized mice during short-term inhalation exposure to chlorine. Subchronic toxicity of Baltic herring oil and its fractions in the rat I:: Fractionation and levels of organohalogen pollutants. How are asthmatics included in the derivation of guideline values for emergency planning and response?
I am deeply committed to outreach and communicating knowledge about the health risks of chemicals. Sedan landar vi i talet där vi nu lever med hundra gånger mer bly i kroppen än stenåldersmänniskan hade. Mattias Öberg Principal Researcher Docent. Subchronic toxicity of Baltic herring oil and its fractions in the rat II:: Clinical observations and toxicological parameters.